The vaccination (Inoculation) for smallpox does not appear to have been widespread until the reign era of (1567–1572).
In China, powdered smallpox scabs were blown up the noses of the healthy. The patients would then develop a mild case of the disease and from then on were immune to it.
Inoculation was practiced in China, Africa, India well before the practice arrived in Europe.
Once Europe and British discovered the the cure they deliberately infected Native American Tribes killing millions.
The practice had been known in Boston since 1706, when Cotton Mather (of Salem witch trial fame) discovered his slave, Onesimus had been inoculated while still in Africa, and many slaves imported to Boston had also received inoculations.
But not the indians or Native American Tribes, they were banned from entering communities and usually were been hunted. It was mandatory for soldiers to be Inoculated before hunting down Natives so they wouldn't be infected. It was also mandatory for slaves so the masters would have workers.
British Captain Simeon Ecuyer, portrayed by Ken Treese, second from right, offered blankets infected with smallpox to the Indians besieging Fort Pitt. Date - June 22 – August 10, 1763
The Siege of Fort Pitt took place during June and July of 1763 in what is now the city of Pittsburgh, Pennsylvania, United States. The siege was a part of Pontiac's War, an effort by Native Americans to remove the British from the Ohio Country and Allegheny Plateau after they refused to honor their promises and treaties to leave voluntarily after the defeat of the French.
The Native American efforts of diplomacy, and by siege, to remove the British from Fort Pitt ultimately failed. This event is best known for the use of biological warfare, where the British gave items from a smallpox infirmary as gifts to Native American emissaries with the hope of spreading the deadly disease to nearby tribes.
Fort Pitt was built in 1758 during the French and Indian War, on the site of what was previously Fort Duquesne in what is now the city of Pittsburgh, Pennsylvania, United States. The French abandoned and destroyed Fort Duquesne in November 1758 with the approach of General John Forbes's expedition.
The Forbes expedition was successful in part because of the Treaty of Easton, in which area American Indians agreed to end their alliance with the French. American Indians, primarily the Six Nations, Delawares and Shawnees, made this agreement with the understanding that the British would leave the area after their war with the French. The hostilities between the French and English declined significantly after 1760, followed by a final cessation of hostilities and the formal surrender of the French at the Treaty of Paris in February 1763.
Instead of leaving the territory west of the Appalachian Mountains as they had agreed, the British remained on Native lands and reinforced their forts while settlers continued to push westward.
The attacks led by Pontiac against the British in early May 1763, near Fort Detroit, mark what is generally considered to be the beginning of Pontiac's War. The siege of Fort Pitt and numerous other British forts during the spring and summer of 1763 were part of an effort by American Indians to reclaim their territory by driving the British out of the Ohio Country and back across the Appalachian Mountains.
While many of the forts and outposts in the region were destroyed, the Indian effort to remove the British from Fort Pitt ultimately failed.
The idea behind this radical new treatment came from Africa, specifically from a slave named Onesimus, who shared his knowledge with Cotton Mather, the town’s leading minister and his legal owner.
"Out of our regard to them we gave them two Blankets and an Handkerchief out of the Small Pox Hospital. I hope it will have the desired effect." William Trent, William Trent's Journal at Fort Pitt.